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Am. J. Trop. Med. Hyg., 30(5), 1981, pp. 1071-1077
Copyright © 1981 by The American Society of Tropical Medicine and Hygiene

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Morphogenesis of Yellow Fever Virus in Aedes aegypti Cultured Cells

II. An Ultrastructural Study

V. Deubel, J. P. Digoutte, X. Mattei AND D. Pandare
Department of Virology, Institut Pasteur, B. P. 220, Dakar, Senegal, and Faculté des Sciences de Dakar, Senegal

The growth and intracytoplasmic development of two yellow fever virus strains (wild and French neurotropic) were studied in Aedes aegypti cells (clone C 17). Despite a longer period of latency for the vaccine virus, infected cells appeared similar. The cisternae of the rough endoplasmic reticulum (RER) were swollen and formed vesicles which contained the virus. This RER appeared to be the predominant locus of viral synthesis and maturation. Cytopathic effect appeared when the cells were filled with vesicles, and it was characterized by cell degeneration and lysis.

Accepted for publication January 10, 1981.






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Copyright © 1981 by the American Society of Tropical Medicine and Hygiene.