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Correlation between Circulating Antigens Detected by the Radioimmunoprecipitation-Polyethylene Glycol Assay (Ripega) and C1q-Binding Immune Complexes in Human Schistosomiasis Mansoni^*

Ferrucio Santoro, Aluizio Prata, Antônio E. Silva AND André Capron

Circulating schistosome antigens (CSA) and circulating immune complexes (CIC) were investigated in serum from 420 patients infected with Schistosoma mansoni. The radioimmunoprecipitation-polyethylene glycol assay with [¹²⁵I] anti-S. mansoni rabbit antibodies appeared as a sensitive and specific method to quantify CSA. In fact, more than 75% of the patients showed significant levels of CSA. C1q-binding CIC were also detected in 70% of subjects with schistosomiasis. In addition, a close correlation was observed between levels of CSA and CIC. These data suggest that part of the CIC present in human schistosomiasis are formed by schistosome specific antigens.

Accepted for publication November 15, 1980.

^* This investigation was supported by grants from the CNRS (ERA 422), INSERM (U 167), CNPq, and the WHO Special Programme for Research and Training in Tropical Diseases.

Address reprint requests to: Professor André Capron, Centre d'Immunologie et de Biologie Parasitaire, Institut Pasteur, 15 rue Camille Guérin, B.P. 245, 59019 Lille Cedex, France.

Present address: Department of Pathology, New York University Medical Center, New York, New York 10016.