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Susceptibility of Laboratory Primates to Infection with Mansonella Ozzardi from Man^*

The study was undertaken to determine whether primates were susceptible to infection with Caribbean and/or Amazon strains of Mansonella ozzardi of man. Twenty-three animals including three chimpanzees, four squirrel monkeys, one capuchin, five rhesus and 10 patas monkeys each received, by subcutaneous or intraperitoneal injection, 25–170 infective larvae of M. ozzardi harvested either from infected Culicoides furens collected in Haiti or Simulium sp. (sanguineum complex) collected in the Colombian Amazon and transported to our laboratories in Louisiana. Patent infections were obtained in seven of 10 patas monkeys but not in any other species of primates. The prepatent period ranged in duration from 149–186 days with a mean of 168 days. All of the patas monkeys developed modest microfilaremias that persisted for as long as 1 year, the duration of our observations. Adult worms were obtained at necropsy from three of four patas monkeys. The worms were recovered from soakings of the carcass and skin rather than from the abdominal cavity and mesenteries. However, their precise habitat was not determined.

Accepted for publication January 31, 1981.

^* This study was supported by Grant AI 10050, National Institute of Allergy and Infectious Diseases, National Institutes of Health, to the Tulane University, International Center for Medical Research, and by U.S.P.H.S. Grant RR 00164, Division of Research Resources, National Institutes of Health.

Address reprint requests to: Dr. Thomas C. Orihel, International Center for Medical Research, Tulane University, 1430 Tulane Avenue, New Orleans, Louisiana 70112.