AJTMH ASTMH MEMBERSHIP INFORMATION: astmh@astmh.org
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 30(4), 1981, pp. 780-789
Copyright © 1981 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Van Marck, E. A. E.
Right arrow Articles by Gigase, P. L. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Van Marck, E. A. E.
Right arrow Articles by Gigase, P. L. J.

Renal Disease in Chronic Experimental Trypanosoma Gambiense Infections*

Eric A. E. Van Marck, Andree Beckers, Andre M. Deelder, Wim Jacob, Marc Wery AND Paul L. J. Gigase
Departments of Pathology and Protozoology, Prince Leopold Institute of Tropical Medicine, Antwerp, Belgium, State University Leiden, Department of Parasitology, Leiden, The Netherlands, and Universitaire Instelling Antwerpen, Laboratory of Electron Microscopy, Wilrijk, Belgium

Two recently isolated stocks of Trypanosoma brucei gambiense of human origin gave rise to a moderate to severe proliferative or membranoproliferative glomerulonephritis in 40 or 44 NMRI and C57BL/6J mice infected for 7–22 weeks. Extensive granular deposits of C3, IgG1 and IgG3 were found in the mesangium, together with smaller quantities of IgG2a, IgG2b, and IgM. No trypanosomal antigen could be detected in the deposits though specific anti-trypanosoma antibodies were found in kidney eluates. By electron microscopy, a conspicuous proliferation of mesangial and endothelial cells was observed and electrondense deposits were seen in a mesangial and subepithelial localization. With one of these trypanosome stocks, four of seven Wistar rats infected for 9–15 weeks developed morphologically similar glomerular lesions. Four other trypanosome stocks did not evoke renal alterations in 17 other rats infected for 13–56 weeks. Experimental infection in mice or rats appears to be a suitable model for the study of renal disease in chronic African sleeping sickness.

Accepted for publication December 6, 1980.


* An abstract of this work has been published in the Abstract Book of the 4th International Congress of Immunology (of the International Union of Immunological Societies IUIS), Paris, July 21–26, 1980.

Address reprint requests to: Dr. E. A. E. Van Marck, Prince Leopold Institute of Tropical Medicine, Department of Pathology, Nationalestraat 155, B-2000 Antwerp, Belgium.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1981 by the American Society of Tropical Medicine and Hygiene.