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Salmonella Paratyphi a in Hamsters Concurrently Infected with Schistosoma Mansoni^*

Isis A. Mikhail, Gene I. Higashi, Noshy S. Mansour, David C. Edman AND Sabry H. Elwan

The present work deals with the development of an improved animal model to study the association of salmonellosis and schistosomiasis. The animal chosen was the hamster, Mesocricetus auratus, which can be readily infected with Schistosoma mansoni. Normal hamsters and schistosome-infected hamsters (SIH) were given approximately 2.0 x 10⁷ Salmonella paratyphi A intracardially. It was found that S. mansoni infections enhanced and prolonged the growth of S. paratyphi A in hamsters. Animals with dual infections had increased mortality in comparison with those infected with just bacteria or parasite during the 50 days post-bacterial challenge. Further studies showed that in SIH, S. paratyphi A persisted in various organs for up to 8 weeks post infection. In contrast, concurrent Leishmania donovani infections have no effect on S. paratyphi A infections. Significant numbers of bacteria were cultured from well-washed schistosome worms recovered from SIH 6–8 weeks post-bacterial challenge. These findings suggest that a direct physical relationship between the bacteria and worms facilitates the establishment and growth of S. paratyphi A in vivo, and that a deficit in host immune response is not a major factor involved in the enhanced growth of S. paratyphi A.

Accepted for publication August 23, 1980.

^* The opinions and assertions contained herein are the private ones of the authors and are not to be construed as official or as reflecting the views of the Department of the Navy or the naval service at large. This work was supported by the Naval Medical Research and Development Command, Bethesda, Maryland, under Work Unit No. 61152N MR0000101-3030.

Present address: Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan 48109.

Present address: Department of Microbiology, Royal Medical Research Institute, National Naval Medical Center, Bethesda, Maryland 20014.