HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Berman, J. D. Articles by Neva, F. A. Search for Related Content PubMed PubMed Citation Articles by Berman, J. D. Articles by Neva, F. A.

Effect of Temperature on Multiplication of Leishmania Amastigotes within Human Monocyte-Derived Macrophages in Vitro

Leishmania tropica, a cause of cutaneous leishmaniasis, multiplied more rapidly within human macrophages in vitro at 35°C than at 37°C, and was almost completely eliminated at 39°C. In contrast, Leishmania donovani, the cause of the visceral leishmaniasis, multiplied equally well at 35°C and at 37°C, and was only 40% eliminated at 39°C. This in vitro study suggests that the localization of the two strains to cooler and warmer regions of the body, respectively, is at least partially explained by the inherent temperature sensitivity of the parasite-macrophage unit. The striking elimination of this strain of L. tropica within macrophages at 39°C may make this model suitable for predicting the clinical response of cutaneous strains to heat therapy.

Accepted for publication August 16, 1980.