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Experimental Babesia Microti Infections in Macaca Mulatta: Recurrent Parasitemia before and after Splenectomy^*

To learn more about the course of Babesia microti infections in primates, six Macaca mulatta monkeys with blood-induced B. microti infections were followed for 270 days with regular thick blood smears. Three of the monkeys experienced from 1–3 recurrences of parasitemia defined here as 200 organisms/mm³ blood. Following splenectomy on day 297, parasitemia recurred in all animals, reaching levels of 1.9 x 10⁵ to 2.7 x 10⁶ organisms/mm³, and was associated with a moderately severe hemolytic anemia. These findings suggest that similar recurrences of parasitemia may occur in human cases, and that splenectomy may present a risk to persons with a past history of B. microti infection.

Accepted for publication August 23, 1980.

^* Address reprint requests to: Trenton K. Ruebush II, M.D., Bureau of Tropical Diseases, Center for Disease Control, Atlanta, Georgia 30333.

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