HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Aikawa, M. Articles by Furrow, R. Search for Related Content PubMed PubMed Citation Articles by Aikawa, M. Articles by Furrow, R.

Dirofilariasis

IV. GLOMERULONEPHROPATHY INDUCED BY DIROFILARIA IMMITIS INFECTION

The kidneys of dogs chronically infected with Dirofilaria immitis were studied by light, electron, and immunofluorescent microscopy. The glomeruli of dogs with high microfilaremia showed a moderately increased mesangium and thickened glomerular basement membrane. There was a deposition of electron-dense particles which were continuously distributed in the lamina rara interna and lamina densa of the glomerular basement membrane. Immunofluorescent microscopy showed intense IgG deposits in a uniform linear pattern along the glomerular basement membrane. This linear deposition of IgG appeared to correspond to continuous distribution of electron-dense particles in the basement membrane. Microfilariae present in the glomerular capillary lumens were connected with the capillary endothelial cells by narrow cytoplasmic bands. The interaction of the worm's internal substances with the glomerular capillaries through these cytoplasmic bands may deposit worm antigen on the glomerular capillary wall before antigen-antibody interaction takes place. These findings suggest that the glomerulopathy seen in dogs infected with D. immitis is caused by the in situ formation of immune complexes in the glomerular basement membrane.

Accepted for publication June 14, 1980.