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Tissue-Reacting Immunoglobulins in Patients with Different Clinical forms of Chagas' Disease^*

Antibodies against endocardium, blood vessels, interstitium, and plasma membrane of skeletal and heart muscle cells (EVI), as well as antibodies against structures from peripheral nerve (PN), were studied in serum samples from 27 individuals with negative Trypanosoma cruzi serology and 102 seropositive individuals with or without Chagas' disease from the State of Goiás, Brazil. Although significantly higher titers of EVI and PN antibodies were found in some of the seropositive individuals their presence was not correlated with the clinical symptoms and signs which characterize the chronic stage of the disease, nor with the severity of the disease.

Accepted for publication May 10, 1980.

^* This study was made possible by funds provided by the Brazilian Research Council (CNPq), Financiadora de Estudos e Projetos (FINEP), Brazil, and the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases.

Address reprint requests to: Ana Szarfman, M.D., Institute of Microbiology, U.F.R.J., Cidade Universitaria, Ilha Fundao 20000, Rio de Janeiro, R.J., Brazil.