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Comparative Efficacies of Quinine and Chloroquine as Companions to Primaquine in a Curative Drug Regimen^*

L. H. Schmidt

A comparison has been made of the capacities of chloroquine and quinine to serve as companions to primaquine in curing established infections with sporozoites of the M or B strains of Plasmodium cynomolgi in rhesus monkeys. The results indicated that chloroquine was slightly but consistently more effective than quinine in this role. This finding provides support for use of chloroquine as the companion blood schizonticide in the current experimental animal-based search for improved tissue schizonticidal drugs, and bolsters the rather tenuous base for clinical use of this 4-aminoquinoline, rather than quinine, as a companion to primaquine in suppressive-curative and radical-curative regimens.

Accepted for publication July 5, 1980.

^* The experimental studies recorded in this report were supported in part by PHS Research Grants RG 47 and E-8 to The Christ Hospital Institute for Medical Research, Cincinnati, Ohio, and Contract DADA 17-69-C-9104 between the U.S. Army Medical Research and Development Command and Southern Research Institute, Birmingham, Alabama. Manuscript preparation has been supported in part by this contract and in part by the Southern Research Institute. This is contribution number 1578 from the Army Research Program on Antiparasitic Drugs.

Address reprint requests to: L. H. Schmidt, Department of Pharmacology, The Medical Center, University of Alabama in Birmingham, Box 191, University Station, Birmingham, Alabama 35294.

Present address: Department of Pharmacology, The Medical Center, University of Alabama in Birmingham, Birmingham, Alabama 35294.

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