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Oropouche Virus

IV. LABORATORY TRANSMISSION BY CULICOIDES PARAENSIS^*

Instituto Evandro Chagas, Fundaço Servicos de Saúde Pública, Brazilian Ministry of Health, Belém, Brazil, and Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D.C. 20012

Biological transmission of Oropouche (ORO) virus by Culicoides paraensis (Goeldi) has been successfully demonstrated in the laboratory. Adult Culicoides, collected in an area where ORO virus was absent, were infected by feeding on viremic hamsters and then periodically exposed to susceptible hamsters at specific intervals post-infectious blood meal. These C. paraensis were capable of biological transmission of the virus 4–9 days post-feeding on viremic hamsters circulating 6.7–9.9 log₁₀SMLD₅₀/ml virus. Infection rates of 54% and 80% were found for C. paraensis assayed 7 days post-feeding. Virus transmission rates for these experiments were 83% and 25%, respectively. No evidence of mechanical transmission of ORO virus by C. paraensis was observed when interrupted feeding of Culicoides on viremic hamsters was followed by feeding on susceptible hamsters.

Accepted for publication July 12, 1980.

^* Part of this research was carried out with funds from the Polamazonia Program of the Superintendencia de Desenvolvimento da Amazonia. It was conducted in conjunction with PAHO Project BRA 4311 with research supported, in part, by research contract number DAMD 17-74-G-9387 from U.S. Army Medical Research and Development Command, Office of the Surgeon General, Washington, D.C. The opinions contained herein are those of the authors and should not be construed as official or reflecting the views of the Department of the Army.

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