HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Tobie, E. J. Search for Related Content PubMed PubMed Citation Articles by Tobie, E. J.

The Effect of Puromycin on Six Species of Trypanosoma in Mice

The antibiotic Puromycin produced from a species of Actinomyces, Streptomyces albo-niger, was tested for its trypanocidal properties against Trypanosoma equiperdum, T. equinum, T. evansi, T. rhodesiense, T. gambiense, and T. congolense infections in mice. The data presented in this report show that when treatment with Puromycin was begun approximately four hours after inoculation with these species of Trypanosoma all except T. congolense were prevented from developing. Administration of the drug four days prior to inoculation with trypanosomes did not prevent infections from progressing. When treatment was initiated at the height of infection the drug had a strong suppressive effect against all species except T. congolense. This effect was greater against those of the evansi group, T. equiperdum, T. evansi and T. equinum, than those of the brucei group, T. rhodesiense and T. gambiense. It is encouraging that this antibiotic has this powerful effect against these trypanosome infections.