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The Treatment of Acute Malaria with Single Oral Doses of Amodiaquin, Chloroquine, Hydroxychloroquine and Pyrimethamine¹

One thousand and twenty Hondurans were treated for acute malaria with a single oral dosage of either amodiaquin (Camoquin), chloroquine (Aralen), hydroxychloroquine (Plaquenil) or pyrimethamine (Daraprim). In general, clinical response was excellent, treatment failures were few, relapses were infrequent, drug toxicity was negligible. The results with pyrimethamine were not equal to the results obtained with the three 4-aminoquinolines. Obviously, it is of great advantage to have several antiplasmodial agents that can be used in single oral dosage for mass treatment.

¹ Portions of this paper were included in addresses presented at the Fifth International Congresses of Tropical Medicine and Hygiene, Istanbul, August 30, 1953; at the annual meeting of the American Society of Tropical Medicine and Hygiene, Louisville, November 12, 1953; and at the Inter-American Medical Convention, Panama City, March 25, 1954.