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Experiments in the Therapy of Human Ascariasis¹

We have described tests with six ascaricidal compounds—diethylcarbamazine (Hetrazan®), sodium santoninate, Nematolyt®, hexylresorcinol monoacetate, hexylresorcinol and a chenopodium-chloroform mixture. None of the results are considered outstanding, but some are encouraging. Of the various single-dose treatments, hexylresorcinol gave the best results with only 42 per cent cures, the chenopodium mixture was next with 40 per cent cures, and the 500 mg. sodium santoninate dosage next with 25.7 per cent. Of the several multiple dose schedules described, diethylcarbamazine in the amount of 12 mg./pound/day for 4 days was the most promising (80 per cent cures) and sodium santoninate in the amount of 250 mg. daily for six days was next with 53.3 per cent. It would seem that in Honduras at least, there is a real need for a more efficient ascaricidal agent.

¹ A portion of this paper was presented at the annual meeting of the American Society of Tropical Medicine and Hygiene, Louisville, Kentucky, November 12–14, 1953.