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Treatment of Experimental Trichinosis in Mice with Piperazine Hydrochloride¹

Piperazine hydrochloride in daily doses of 1,500 mg/kg. is effective against experimental trichinosis in mice. From 76 to 92 per cent of the adult worms are removed by a 7-day course of the drug. It is suggested that daily doses of 2 to 3 grams of piperazine citrate be tried in human cases of trichinosis.

¹ Acknowledgment is made to the Wellcome Research Laboratories (U.S.A.) for furnishing the piperazine hydrochloride used in this study and to Miss Sydell Kopilof for her valuable technical assistance.

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				R. C. JUNG and E. C. FAUST THE TREATMENT OF INTESTINAL PARASITIC INFECTIONS Arch Intern Med, October 1, 1956; 98(4): 495 - 504. [Abstract] [PDF]