AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 3(4), 1954, pp. 672-675
Copyright © 1954 by The American Society of Tropical Medicine and Hygiene

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Relationship between Time of Administration, Dose, and Prophylactic Activity of Pyrimethamine on Sporozoite-Induced Plasmodium Gallinaceum Infections

Joseph Greenberg, G. Robert Coatney AND Helen Louise Trembley
National Institutes of Health, National Microbiological Institute, Laboratory of Tropical Diseases, Bethesda 14, Maryland

In studying the relationship between time of administration and dose of pyrimethamine against Plasmodium gallinaceum in young chicks, it was found that with single oral doses the infection could be eradicated even if treatment was withheld up to and including day 6. A greater percentage of chicks not cured by early treatment died of exoerythrocytic infection than of those not cured by treatment given later.






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Copyright © 1954 by the American Society of Tropical Medicine and Hygiene.