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Am. J. Trop. Med. Hyg., 3(3), 1954, pp. 511-517
Copyright © 1954 by The American Society of Tropical Medicine and Hygiene

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The Effect of Schistosoma Mansoni Infections on Liver Function in Mice

I. Amino Acid Oxidase and Ammonia1

Jack Daugherty, Seymour Garson AND Donald Heyneman
U. S. Army Tropical Research Medical Laboratory, San Juan; and The Rice Institute, Houston, Texas

Preliminary studies on the effects of S. mansoni infections in mice gave evidence of an increased liver size, an increased water content of the liver, a decreased oxidative deamination of amino acids, and a failure in ammonia metabolism. These results are discussed in relation to the structural changes in the liver that accompany the infection.


1 This study was sponsored by the Army Medical Service Graduate School, and was supported (in part) by the Medical Research and Development Board, Office of the Surgeon General, U. S. Army, Washington, D. C.







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