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The Efficacy of Piperazine Compounds against Syphacia Obvelata, a Pinworm of Mice¹

The activity of thirty-two piperazine compounds has been tested against Syphacia obvelata in mice, and several of them exhibited considerable anthelmintic activity. In general, the simple piperazine base and its salts appear to be more effective against Syphacia than are the more complex substituted compounds which were studied. Mature stages of the worm are more vulnerable to piperasine than the immature stages.

¹ The piperazine compounds used in this study, except "Hetrazan," were supplied by The Burroughs Wellcome Company, U. S. A. We also wish to acknowledge their financial support of this project. Miss Sydell Kopilof rendered valuable technical assistance in this study.