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Am. J. Trop. Med. Hyg., 3(2), 1954, pp. 225-231
Copyright © 1954 by The American Society of Tropical Medicine and Hygiene

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Antimalarial Activity of Dihydrotriazines1

R. I. Hewitt, W. S. Wallace, A. Gumble, E. White AND J. H. Williams
Lederle Laboratories Division, American Cyanamid Company, Pearl River, N. Y.

Data are given regarding the effects of several dihydrotriazines against P. lophurae in ducks or P. berghei in mice. A number of the compounds tested were more active than quinine, primaquine, chlorguanide and chloroquine against P. berghei. Among the most active were 4,6-diamino-1-(3,4-dichlorophenyl)-1,2-dihydro-2-methyl-s-triazine and 4,6-diamino-1-(3,4-dichlorophenyl)-1,2-dihydro-2,2-dimethyl-s-triazine.


1 The dihydrotriazines discussed herein were prepared in the laboratories of the Children's Cancer Research Foundation, Boston, Massachusetts, and were submitted to us by Dr. Sidney Farber for evaluation of activity against various types of animal parasites. We are indebted to Dr. Farber and his colleagues for supplying these compounds.






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Copyright © 1954 by the American Society of Tropical Medicine and Hygiene.