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Am. J. Trop. Med. Hyg., 29(6), 1980, pp. 1215-1219
Copyright © 1980 by The American Society of Tropical Medicine and Hygiene

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Intradermal Reactivity of Excretory and Secretory Products of Onchocercal Microfilariae*

Everett L. Schiller, Robert D'Antonio AND Horacio Figueroa Marroquín
Department of Pathobiology, The Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland 21205, and University of San Carlos, Guatemala City, Guatemala, C.A.

The intradermal reactivity of excretory and secretory (ES) products derived from the in vitro cultivation of onchocercal microfilariae was evaluated. The ES products from Onchocerca volvulus were highly sensitive in the detection of active onchocerciasis in both Liberian and Guatemalan subjects. A low level of cross-reactivity occurred in patients with loaisis and in dogs with Dipetalonema reconditum, but not in dogs with Dirofilaria immitis. ES products from O. gutturosa evoked reactions in Guatemalan subjects, but were not as sensitive as those from O. volvulus.

Accepted for publication June 16, 1980.


* This work was supported by grant no. 1R22 AI 16035-01 TMP from the National Institutes of Health.






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Copyright © 1980 by the American Society of Tropical Medicine and Hygiene.