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Prospects and Problems in the Use of Recombinant DNA for the Production of a Malaria Vaccine^*

Recent advances in malaria immunology and the discovery of an in vitro culture method for Plasmodium falciparum have opened the way for the feasibility of formulating a vaccine as a control measure for this most virulent species of human malaria. The successful use of recombinant DNA technology for the production of scarce cellular constituents has made available a great option for mass synthesis of malaria antigens, which otherwise could be prohibitive if it were to depend on the use of human serum and cells. The translation of feasibility to reality of production of a practical human malaria vaccine will depend on the definition of a safe and effective antigen.

^* Supported by National Institute of Allergy and Infectious Diseases Grant AI-13728 and by funds from the malaria component of the UNDP/WORLD Bank/WHO Special Programme for Research and Training in Tropical Diseases.