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Am. J. Trop. Med. Hyg., 29(5_Part_2), 1980, pp. 1085-1088
Copyright © 1980 by The American Society of Tropical Medicine and Hygiene

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New Insights into How Bacteria Take up DNA during Transformation

Hamilton O. Smith
Department of Microbiology, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205

Haemophilus influenzae possesses an efficient natural transformation system. Under appropriate growth conditions, every cell in a culture acquires the competence to take up several molecules of DNA. Only donor DNAs from Haemophilus species are taken up; foreign DNAs are excluded. Specific recognition is achieved through the interaction of a receptor protein present on the recipient cell membrane with an 11 base pair sequence present at high frequency in the donor DNA.






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Copyright © 1980 by the American Society of Tropical Medicine and Hygiene.