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Am. J. Trop. Med. Hyg., 29(4), 1980, pp. 635-637
Copyright © 1980 by The American Society of Tropical Medicine and Hygiene

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Transmission of Dengue 1 and 2 Viruses in Greece in 1928*

Scott B. Halstead AND George Papaevangelou
Department of Tropical Medicine and Medical Microbiology, John A. Burns School of Medicine, 3675 Kilauea Avenue, Honolulu, Hawaii 96816 and the Department of Epidemiology and Medical Statistics, Athens School of Hygiene, Athens, Greece

In August-September 1928 approximately 650,000 residents of Athens and Piraeus contracted dengue fever, and 1,061 died. We were interested in the etiology of this severe epidemic in which many cases resembled dengue hemorrhagic fever or the dengue shock syndrome, and have attempted a retrospective seroepidemiological study. Serum specimens were obtained from 111 residents of Athens or Piraeus who were born in 1927 or 1928, and were studied by plaque reduction neutralization test for antibodies to dengue 1–4 viruses. Of 75 persons born in 1928, 20 (27%) had monospecific dengue 1, 10 (13%) had monospecific dengue 2, and 1 (1%) had dengue 1 and 2 neutralizing antibodies. When prevalence of neutralizing antibody was analyzed by month of birth in 42 individuals, evidence of both dengue 1 and 2 infections was found in persons born in January–July, but only dengue 2 antibody was detected in those who were born after July. This study dates dengue 1 and dengue 2 transmission to 1928, allowing for the possibility that sequential infections with these viruses could have played a pathogenetic role in the outbreak.

Accepted for publication October 6, 1979.


* This study was supported by Grant HD 08693 from the National Institute of Child Health and Human Development. We thank Susan Hatch, Linda Kay Larsen, and Carrie Uyehara for valuable technical assistance.




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