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Applicability of Different Antigen Preparations in the Enzyme-Linked Immunosorbent Assay for Schistosomiasis mansoni^*

The applicability of seven different antigen preparations for the detection of antibodies against Schistosoma mansoni was tested in the enzyme-linked immunosorbent assay. For this purpose, sera from children and adults from Surinam infected with S. mansoni were screened for the presence of specific antibodies against the various antigens. With all antigens, generally better results were obtained with the sera from children than with those from adults. The best results were obtained when the trichloroacetic acid-soluble fraction of adult worm antigen (containing the proteoglycan circulating anodic antigen) was used.

Accepted for publication September 15, 1979.

^* This investigation received financial support from the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases, and from the ALCOA Foundation, Paramaribo.

Addresss reprint requests to: Dr. A. M. Deelder, Laboratory of Parasitology, University of Leiden, Rapenburg 33, Leiden, Netherlands.