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Variable Severity of Glomerulonephritis in Inbred Rats Infected with Trypanosoma rhodesiense

Correlation with Immunoglobulin Class-specific Antibody Responses to Trypanosomal Antigens and Total IgM Levels^*

Herbert B. Lindsley, Raymond B. Nagle, Philip A. Werner AND Daniel J. Stechschulte

Five strains of inbred rats (ACI, BUF, F344, WF and WL) were infected with Trypanosoma rhodesiense and killed at 28 days for renal pathology and serological studies. The BUF strain demonstrated the most consistent and severe glomerulonephritis, accompanied by high titer IgM antibodies to trypanosomes and high total IgM levels. The WL strain demonstrated mild glomerulonephritis but prominent PAS (+) intracytoplasmic inclusions in proximal convoluted tubules, accompanied by low titer IgM antibodies and slightly elevated total IgM levels. All strains had low to medium titer IgG1 and IgGa antibodies to trypanosomes. Serial serologic studies in BUF rats showed peak titers of IgM, IgGa and IgG1 antibodies to trypanosomal antigens at 10 days. Immune complexes as measured by a C1q binding assay were elevated at 10 days, 3 days following the first detectable antibody responses, and remained so through the 30th day.

Accepted for publication August 4, 1979.

^* This work was supported in part by the U.S. Army Medical Research and Development Command (DAMD 17-74-C-4136).

The experiments reported herein were conducted according to the principles set forth in the "Guide for the Care and Use of Laboratory Animals," Institute of Laboratory Resources, National Research Council, DHEW Publication No. (NIH) 74-23.

Department of Pathology, University of Arizona Health Sciences Center, Tucson, Arizona 85724.