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Am. J. Trop. Med. Hyg., 29(3), 1980, pp. 339-342
Copyright © 1980 by The American Society of Tropical Medicine and Hygiene

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*CHLOROQUINE

Plasmodium falciparum in Vitro: Determination of Chloroquine Sensitivity of Three New Strains by a Modified 48-Hour Test

Phuc Nguyen-Dinh AND William Trager
Laboratory of Parasitology, The Rockefeller University, New York City, New York 10021

Three recently isolated African strains of Plasmodium falciparum were tested in vitro for their response to chloroquine. Both the 48-hour method described earlier and a modified 48-hour test were used, yielding comparable results. Strain FCR-7/Kenya, isolated from a clinically chloroquine-resistant case, was more resistant to the drug in vitro than the two other strains (FCR-8/West Africa and FCN-1/Nigeria, both isolated from chloroquine-sensitive cases). Complete inhibition of parasite growth occurred for strain FCR-7/Kenya in a drug concentration range ten times higher than for strains FCR-8/West Africa and FCN-1/Nigeria. In the modified 48-hour test, a lower erythrocyte suspension (2%) allows continuous growth of the parasites over a 48-hour cycle without necessitating change in medium. It thus offers distinct advantages for routine laboratory work as well as for potential field trials.

Accepted for publication August 25, 1979.




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