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Effect of Unisexual Schistosoma Mansoni Infections on Hepatic Drug Metabolism of Mice^*

The effect of unisexual schistosome infection on the activities of several hepatic enzymes was studied in mice. The activities of hepatic drug-metabolizing enzymes in mice infected with either female or male schistosomes were not significantly different from those of noninfected control animals. However, the total amount of heme pigment in the liver of infected mice was 2.7 (female infection) and 8.9 (male infection) times greater than that of control animals. The durations of hexobarbital sleeping times and of zoxazolamine paralysis in unisexual schistosome infections did not differ from those of uninfected controls. Therefore, an accumulation of schistosome pigment without egg deposition, as in this unisexual infection study, does not result in a severe reduction of hepatic drug-metabolizing capacity.

Accepted for publication April 28, 1979.

^* This investigation was supported by grants and contracts from the National Institutes of Health (GM 16492) and the Agency for International Development (AI-08022).

This article has been cited by other articles:

				E. Conford and M. Huot Glucose transfer from male to female schistosomes Science, September 11, 1981; 213(4513): 1269 - 1271. [PDF]