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Circulating Immune Complexes and Anti-IgG Antibodies in Mucocutaneous Leishmaniasis^*

Philippe Desjeux, Ferrucio Santoro, Daniel Afchain, Marc Loyens AND André Capron

Circulating immune complexes (CIC), anti-IgG, anti-DNA, and anti-collagen autoantibodies (Ab) were investigated in sera from patients with South American leishmaniasis. No significant levels of anti-DNA or anti-collagen autoantibodies were observed. Only a few patients with cutaneous leishmaniasis or with only one mucocutaneous lesion showed values for CIC and anti-IgG Ab higher than those in the control group. In contrast, both CIC and anti-IgG Ab were demonstrated in most patients with several lesions due to mucocutaneous leishmaniasis (MMC). Moreover, a close correlation was noticed between the detection of CIC and anti-IgG Ab in MMC patients. This relationship suggested that part of the detected CIC could have been formed by IgG-anti-IgG complexes. The involvement of these immunopathologically active substances in the clinical evolution of mucocutaneous leishmaniasis is discussed.

Accepted for publication June 30, 1979.

^* This investigation was supported by grants from the CNRS (ERA 422) and INSERM (U 167).

Address reprint requests to: Dr. Ferrucio Santoro, Centre d'Immunologie et de Biologie Parasitaire, Institut Pasteur, B.P. 3415, 59019—Lille Cedex, France.

Present address: Institut Pasteur de Dakar, B.P. 220, Dakar, Senegal.