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Therapeutic Efficacy of Oral Oxamniquine in the Toxemic form of Schistosomiasis Mansoni: Treatment of Eleven Individuals from Two Families, and Experimental Study^*

Two families, comprising 11 individuals in the toxemic form of schistosomiasis mansoni, infected in Belo Horizonte, Brazil were treated. Parasitological cure was obtained in 5 (45%) of the patients after a single oral dose of oxamniquine (Mansil®), 20 mg/kg body weight. No significant side effects were observed. To evaluate the possibility of resistance to the drug, cercariae collected from Biomphalaria glabrata infected with miracidia from eggs obtained from three of the individuals not cured were studied. Mice infected with these three strains were cured after a single oral dose of oxamniquine. It is suggested that research be continued with other therapeutic schedules and perhaps other, more potent, drugs.

Accepted for publication May 19, 1979.

^* Contribution 18 from the Núcleo de Estudos sobre Esquistossomose do Curso de Pós-Graduação em Medicina Tropical da Faculdade de Medicina da Universidade Federal de Minas Gerais, Brazil. The experimental study was supported by a grant from the Conselho Nacional de Desenvolvimento Cientifico e Tecnológico.