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Am. J. Trop. Med. Hyg., 29(1), 1980, pp. 46-49
Copyright © 1980 by The American Society of Tropical Medicine and Hygiene

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Preliminary Observations on the Development of Larval Filariae in Toxorhynchites Species*

John H. Cross, Mei-Yuan K. Hsu AND Jih Ching Lien
U.S. Naval Medical Research Unit No. 2, Taipei, Taiwan, Republic of China

Brugia malayi and B. Pahangi microfilariae from gerbil intraperitoneal infections were inoculated into the thorax of male and female Toxorhynchites amboinensis and developed into third-stage larvae as early as 11 days. In a comparative study with Aedes togoi fed on microfilaremic gerbils, third-stage larvae were found at 10 days. Some third-stage larvae of B. malayi inoculated into gerbils developed to advanced stages. Third-stage larvae of Wuchereria bancrofti were recovered in low numbers from Tx. amboinensis and Tx. aurifiuus inoculated with microfilariae recovered from human blood by membrane filtration. Development of all filarial species was similar in both male and female mosquitoes. Toxorhynchites species are plant feeders and therefore reduce the hazards of laboratory transmission of pathogenic agents. Because of their large size, manipulations with this mosquito species are easy and the size allows for a larger inoculum to be used. This group of mosquitoes should develop into useful laboratory vectors for the transmission of arthropod-borne diseases.

Accepted for publication May 19, 1979.


* This study was supported through funds provided by the Naval Medical Research and Development Command, Navy Department, for Work Unit MR041.09.01-0145.

The research described in this report involved animals maintained in animal care facilities fully accredited by the American Association for Accreditation of Laboratory Animal Care.

The opinions and assertions contained herein are those of the authors and are not to be construed as official or as reflecting the views of the Navy Department.

Address reprint requests to: Publications Office, NAMRU-2, APO San Francisco, CA 96528.






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Copyright © 1980 by the American Society of Tropical Medicine and Hygiene.