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Am. J. Trop. Med. Hyg., 29(1), 1980, pp. 26-30
Copyright © 1980 by The American Society of Tropical Medicine and Hygiene

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Entamoeba Histolytica "Toxin": Fetuin Neutralizable and Lectin-Like

Carl F. T. Mattern, David B. Keister AND Patricia Caspar Natovitz
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205

Extracts of Entamoeba histolytica produce rounding and agglutination of mammalian cells in tissue culture. This effect is inhibited or reversed by serum, by the serum glycoprotein, fetuin, or by N-acetyl-D-galactosamine. Concanavalin A produces a similar cytotoxic effect that is blocked or reversed by {alpha}-methyl mannoside. These properties suggest that the amebal "toxin" has a lectin-like activity.

Accepted for publication June 30, 1979.






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Copyright © 1980 by the American Society of Tropical Medicine and Hygiene.