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Am. J. Trop. Med. Hyg., 28(6), 1979, pp. 937-947
Copyright © 1979 by The American Society of Tropical Medicine and Hygiene

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The Development of a "High Volume Tissue Schizonticidal Drug Screen" Based upon Mortality of Mice Inoculated with Sporozoites of Plasmodium Berghei*

Dora S. Rane AND Kenneth E. Kinnamon{dagger}
The Leo Rane Laboratory, University of Miami, 5750 N.W. 32nd Avenue, Miami, Florida 33142, and Department of Biology, Division of Medicinal Chemistry, Walter Reed Army Institute of Research, Washington, D.C. 20012

A biological test system has been developed to assess the prophylactic activity of compounds against sporozoite-induced Plasmodium berghei malaria in mice. The procedure was designed to serve as the foundation of an effor to develop tissue schizonticidal drugs in a manner parallel to that of a previous system employed in the U.S. Army Antimalarial Drug Development Program to screen compounds for blood schizonticidal activity. In tests with 35 known antimalarial compounds, the new screen was found to be in agreement 93% and 80%, respectively, when assessed compound activity was compared with results obtained in a definitive mouse causal prophylactic test and a rhesus monkey radical curative system.

Accepted for publication March 17, 1979.


* The initial concept for developing this test system was that of Dr. Leo Rane (before his sudden death on 21 June 1973).

In conducting the research described in this report, the investigators adhered to the ‘Guide for Care and Use of Laboratory Animals,’ as promulgated by the Committee of the Guide for Laboratory Animal Facilities and Care of the Institute of Laboratory Animal Resources, National Academy of Sciences—National Research Council.


{dagger} Present address: School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20014.






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Copyright © 1979 by the American Society of Tropical Medicine and Hygiene.