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Am. J. Trop. Med. Hyg., 28(6), 1979, pp. 1036-1039
Copyright © 1979 by The American Society of Tropical Medicine and Hygiene

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Immune Responses in Bats Following Intranasal Infection with Histoplasma Capsulatum*

David N. McMurray{dagger} AND Donald L. Greer{ddagger}
Tulane University-International Center for Medical Research, Apartado Aereo 5390, Cali, Colombia

Groups of bats (Artibeus lituratus) were infected by the intranasal instillation of a suspension of mycelia and spore particles of Histoplasma capsulatum containing either 104 or 106 viable units. Bats infected with the high dose had viable H. capsulatum in the lungs, liver, spleen and gut as early as 2 weeks post-infection. Complement-fixing antibodies to the organism were detectable 3 weeks after infection, whereas precipitating antibodies were not present until 5 weeks. Significant delayed hypersensitivity to histoplasmin was noted at 2 and 4 weeks after infection. By 9 weeks, delayed hypersensitivity had waned, while antibodies could still be demonstrated. The observation that bats are susceptible to respiratory infection with H. capsulatum suggests a mechanism by which the disease may be maintained within a colony. Delayed hypersensitivity appears to be a sensitive, but transient, indicator of active histoplasmosis in bats.

Accepted for publication April 7, 1979.


* Research performed at the Tulane University—International Center for Medical Research, Cali, Colombia, and supported by grant no. AI-10050 from the National Institutes of Health.

Presented in part at the American Society for Microbiology Annual Meeting, Las Vegas, Nevada, May 1978.


{dagger} Present address: Department of Medical Microbiology and Immunology, College of Medicine, Texas A&M University, College Station, Texas 77843.


{ddagger} Present address: Departmento de Microbiologia, Universidad del Valle, Cali, Colombia.






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Copyright © 1979 by the American Society of Tropical Medicine and Hygiene.