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Reversibility of Histopathological changes in the Ovaries in Acute Murine Schistosomiasis Mansoni after Niridazole Treatment

Atrophy of the corpus luteum cells, and nuclear alterations of the interstitial cells, are constantly found in the ovaries of mice with acute Schistosoma mansoni infection. In order to investigate whether these pathological changes are reversible, 2 months after infection of mice niridazole was administered orally for 10 days in a daily dose of 100 mg/kg body weight. Uninfected and infected untreated groups served as controls. The frequency of normal ovaries was much greater in animals cured of infection than in the infected controls. In some animals, unilateral ovariectomy was performed; the histopathological changes in the ovaries removed before treatment were absent in the remaining ovaries 4 weeks after treatment. These findings indicate that ovarian alterations in murine schistosomiasis mansoni can be reversed by adequate antischistosomal treatment.

Accepted for publication January 6, 1979.

^* Present address: Provincial Institute of Hygiene, Nationalestraat 155, B2000-Antwerp, Belgium.