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Am. J. Trop. Med. Hyg., 28(4), 1979, pp. 763-767
Copyright © 1979 by The American Society of Tropical Medicine and Hygiene

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Coagulation Abnormalities Induced by Russell's Viper Venom in the Rhesus Monkey*

K. S. Chugh, D. Mohanthi, Yash Pal AND K. C. Dass
Departments of Nephrology and Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Coagulation studies were carried out in a group of non-human primates (rhesus monkeys) following envenomation with lethal and sublethal doses of Russell's viper venom. The envenomated animals showed significant fibrinogenopenia in association with or without disseminated intravascular coagulation. The findings offer a rational explanation for the bleeding manifestations seen in clinical cases of Russell's viper bite.

Accepted for publication October 7, 1978.


* Address reprint requests to: Dr. K. S. Chugh, Professor and Head, Division of Nephrology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.






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Copyright © 1979 by the American Society of Tropical Medicine and Hygiene.