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Am. J. Trop. Med. Hyg., 28(4), 1979, pp. 701-710
Copyright © 1979 by The American Society of Tropical Medicine and Hygiene

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Epidemic Dengue Hemorrhagic Fever in Rural Indonesia

I. Virological and Epidemiological Studies*

D. J. Gubler{dagger}, W. Suharyono, I. Lubis, S. Eram AND J. Sulianti Saroso
U.S. Navy Medical Research Unit No. 2, Jakarta Detachment, Jakarta, Indonesia, National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia, and Directorate of Prevention and Control of Communicable Disease, Ministry of Health, Yogyakarta, Java, Indonesia

Virological studies were carried out during an epidemic of dengue hemorrhagic fever in Central Java, Indonesia in 1976. Dengue virus was isolated from the acute sera of 45 of 69 patients (65%). The isolation rate was higher in primary than secondary cases. Dengue 3 was the predominant serotype being transmitted (27 isolates), but both dengue 1 (8 isolates) and dengue 4 (10 isolates) were also being transmitted. A composite picture of magnitude and duration of viremia showed that many patients were circulating over 108 MID50 per milliliter dengue 3 virus for the first 3 days of illness and that viremia persisted for 5–6 days in some persons. If all shock cases were considered, there was no relationship between dengue serotype and severity of disease. All three confirmed fatal cases, however, were associated with dengue type 3 infections.

Accepted for publication January 29, 1979.


* This study was supported by funds provided by the Ministry of Health, Indonesia, and the Naval Medical Research and Development Command, Navy Department, for Work Unit No. MR041.09.01-0151. The opinions and assertions contained herein are the private ones of the authors and are not to be construed as official or as reflecting the views of the Ministry of Health, Indonesia or the U.S. Navy Department or the Naval Service at large.

Address reprint requests to: Publications Office, NAMRU-2, APO San Francisco 96528.


{dagger} Present address: University of Illinois, 320 Morrill Hall, Department of Entomology, Urbana, Illinois 61801.






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Copyright © 1979 by the American Society of Tropical Medicine and Hygiene.