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T-Cell Immunity to Malaria in the B-Cell Deficient Mouse^*

D. W. Roberts AND W. P. Weidanz

Some B-cell deficient mice drug-rescued with clindamycin HCl from otherwise lethal infections with Plasmodium yoelii resisted subsequent challenge with the same parasite despite the fact that they lacked detectable antibody to plasmodia. Parasitemias remained patent but at low levels (5%) in these mice for prolonged periods of time, suggesting that some T-cell function independent of antibody formation can in part mediate immunity to malaria.

Accepted for publication September 2, 1978.

^* This work was supported in part by Public Health Service research grant AI-12710 from the National Institute of Allergy and Infectious Diseases.

Present address: National Center for Toxological Research, Jefferson, Arkansas 72709.

This article has been cited by other articles:

				H. C. van der Heyde, J. M. Batchelder, M. Sandor, and W. P. Weidanz Splenic {gamma}{delta} T Cells Regulated by CD4+ T Cells Are Required To Control Chronic Plasmodium chabaudi Malaria in the B-Cell-Deficient Mouse. Infect. Immun., May 1, 2006; 74(5): 2717 - 2725. [Abstract] [Full Text] [PDF]