HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by López-Correa, R. H. Articles by Kuno, G. Search for Related Content PubMed PubMed Citation Articles by López-Correa, R. H. Articles by Kuno, G. Pubmed/NCBI databases Medline Plus Health Information Dengue

Dengue Fever with Hemorrhagic Manifestations: a Report of Three Cases from Puerto Rico

Raúl H. López-Correa^*, Barnett L. Cline, Carlos Ramirez-Ronda, Ramón Bermudez, Gladys E. Sather^* AND Goro Kuno^*

During the 1975 dengue epidemic in Puerto Rico, we studied three patients who had serologically confirmed dengue with hemorrhagic manifestations. None of the patients went into shock and none died. Only one of the patients had disease that resembled dengue hemorrhagic fever (DHF) as observed in Southeast Asia. This patient was a 14-year-old boy who had epistaxis, a positive tourniquet test, moderate thrombocytopenia, and significant hemoconcentration. The other two patients had hemorrhagic disease which was of clinical importance, but was not typical of DHF. These cases of dengue with hemorrhagic manifestations are the only known to have been documented in Puerto Rico.

Accepted for publication June 3, 1978.

^* San Juan Laboratories, CDC, GPO Box 4532, San Juan, Puerto Rico 00936. Send reprint requests here.

Chairman, Department of Tropical Medicine, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana 70112.

Associate Chief of Staff for Research and Development, Veterans Administration Hospital, San Juan, Puerto Rico.

Chief, Infectious Diseases Division, VA Hospital.