HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Cha, Y.-N. Articles by Bueding, E. Search for Related Content PubMed PubMed Citation Articles by Cha, Y.-N. Articles by Bueding, E.

Recovery of the Hepatic Drug-Metabolizing Capacity in Mice Infected with Schistosoma Mansoni Following Curative Chemotherapy with the Schistosomicide 4-Isothiocyano-4'-Nitro-Diphenylamine (CGP 4540)^*

Treatment of mice infected with Schistosoma mansoni with a single oral dose of formulated 4-isothiocyano-4'-nitro-diphenylamine (CGP 4540) restored the capacity of the liver of these animals to metabolize certain drugs. Full recovery required 35–40 weeks. Administration of CGP 4540 to non-infected animals produced no significant changes in the activities of some hepatic drug-metabolizing enzymes.

Accepted for publication June 3, 1978.

^* These studies were supported by grants and contracts from the National Institutes of Health (Nos. AI-08022, GM 16492, and CA #18251), the Agency for International Development, and The Edna McConnell Clark Foundation.