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Inducibility of the Hepatic Drug-Metabolizing Capacity of Mice Infected with Schistosoma Mansoni^*

The activities of some hepatic microsomal drug metabolizing enzymes, which are markedly depressed in mice infected with Schistosoma mansoni, can be increased by treatment with phenobarbital or 3-methylcholanthrene. Administration of these compounds to infected mice increased the capacity of the liver to metabolize drugs up to the maximum level inducible in non-infected animals. However, the increased hepatic microsomal mass, reflected in glucose 6-phosphatase activities and cytochrome b₅ levels, observed in schistosome-infected mice, was not increased further by the same treatment. The changes in the activities of several drug metabolizing enzymes in vitro were confirmed in vivo by determination of hexobarbital-induced sleeping time and zoxazolamine-induced paralysis duration.

Accepted for publication June 3, 1978.

^* This investigation was supported by grants from the Edna McConnell Clark Foundation (No. 274-063), National Institutes of Health (GM No. 16492), and American Cancer Society Institutional Grant.