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Am. J. Trop. Med. Hyg., 27(6), 1978, pp. 1174-1180
Copyright © 1978 by The American Society of Tropical Medicine and Hygiene

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Humoral Immune Responses in Human Hepatosplenic Schistosomiasis Mansoni*

Richard W. Goodgame, Daniel G. Colley, C. C. Draper, Fred A. Lewis, M. L. McLaren AND Ronald P. Pelley
Research and Control Department, Ministry of Health, Castries, St. Lucia, West Indies, Veterans Administration Hospital and Department of Microbiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, Ross Institute of Tropical Hygiene, London School of Hygiene and Tropical Medicine, London WC1E 7HT, England, and Division of Geographic Medicine, Department of Medicine, Case Western Reserve University and University Hospitals, Cleveland, Ohio 44106

The development of hepatosplenic schistosomiasis in humans cannot always be related to the intensity of infection. A study was designed to identify different humoral immunologic responses to Schistosoma mansoni in patients with and without hepatosplenic disease. Twenty-four patients with active hepatosplenic disease were closely matched for age, sex, and fecal egg counts with twenty-four patients with only intestinal disease. A serum sample from each of these patients was tested for antibodies to the major soluble egg antigen (MSA1) by radioimmunoassay, for total and IgM antibodies to egg and worm antigenic preparations by ELISA, and for its ability to suppress antigen stimulated lymphocyte blastogenesis. No difference was found using these assays between the hepatosplenic and the intestinal schistosomiasis patients.

Accepted for publication April 29, 1978.


* This work was supported by the Government of St. Lucia, The Rockefeller Foundation, the Overseas Development Administration, London, U.K., Scheme R. 2108 A-C, The Edna McConnell Clark Foundation, and the Veterans Administration Hospital, Nashville, Tennessee.

Address reprint requests to: Dr. Richard W. Goodgame, Research and Control Department, P.O. Box 93, Castries, St. Lucia, West Indies.






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Copyright © 1978 by the American Society of Tropical Medicine and Hygiene.