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Am. J. Trop. Med. Hyg., 27(6), 1978, pp. 1079-1083
Copyright © 1978 by The American Society of Tropical Medicine and Hygiene

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Immunological Features of Kala-Azar

H. R. Rezai, S. M. Ardehali, G. Amirhakimi AND A. Kharazmi
Departments of Microbiology and Pediatrics, Pahlavi University Medical School, Shiraz, Iran

Serum immunoglobulins, complement C3c, percentage of T and B cells, and skin reactivity to Leishmania were studied in ten cases of kala-azar. Immunoglobulin G was increased in a majority of these patients. The C3c level in two out of six patients tested was lower than normal. The percentage of T cells in peripheral blood of nine patients tested was reduced and in seven of these patients the percentage of B cells was elevated. After a full course of anti-kala-azar therapy the percentage of T and B cells remained the same in five patients studied. All the patients showed a negative skin reaction when they were tested with Leishmania antigen.

Accepted for publication July 22, 1978.






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Copyright © 1978 by the American Society of Tropical Medicine and Hygiene.