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Resistance of Mice to Secondary Infection with Schistosoma Mansoni

II. Evidence for a Correlation Between Egg Deposition and Worm Elimination^*

Mice reinfected with Schistosoma mansoni 6–8 weeks after a primary infection largely or completely eliminated the second infection prior to the 7-week adult worm stage. In contrast, challenge worm counts were not lower than controls at the 6-day lung schistosomulum stage. At reinfection intervals of 12 or more weeks, worm counts were reduced at both stages. The reduction in lung schistosomulum count was proportional to the number of schistosome eggs present in the lungs, with no significant reduction being detected at any challenge time in mice free of lung eggs. Isolated schistosome eggs injected intravenously into the lungs of normal mice induced moderate to high levels of resistance to infection, while eggs injected subcutaneously or intraperitoneally did not. It is concluded that the deposition of schistosome eggs in sites encountered by migrating schistosomula may be essential for mice to become resistant to reinfection with S. mansoni.

Accepted for publication March 25, 1978.

^* This work was supported by the Naval Medical Research and Development Command, Work Unit No. MR041.05.01.0023, Office of Naval Research Contract No. N00014.76.C.0146, and a grant from the Edna McConnell Clark Foundation. The opinions or assertions contained herein are the private ones of the authors and are not to be construed as official or reflecting the views of the U.S. Navy Department or the naval service at large. The experiments reported herein were conducted according to the principles set forth in the "Guide for the Care and Use of Laboratory Animals," Institute of Laboratory Animal Resources, National Research Council, DHEW Publ. No. (NIH) 74-23.