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Renal Amyloidosis with Nephrotic Syndrome in Two Patients with Schistosomiasis Mansoni and Chronic Salmonellosis^*

This report describes two Egyptian patients who presented with the nephrotic syndrome and concurrent infections with Schistosoma mansoni and Salmonella paratyphi A. Unlike similar cases previously reported from this unit, these patients did not respond to antimicrobial and antischistosomal therapy, and their renal biopsies demonstrated amyloidosis. These two case reports and several experimental observations suggest that chronic schistosomiasis and salmonellosis may lead to secondary amyloidosis in susceptible individuals.

Accepted for publication March 11, 1978.

^* Supported by Naval Medical Research and Development Command Work Units M0095.PN002-5022 and MR041.09.01-0153.

The opinions and assertions contained herein are the private ones of the authors and are not to be construed as official or reflecting the views of the Department of the Navy or the naval service at large.

Address reprint requests to: Publications Editor, NAMRU-3, F.P.O. New York 09527.