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Am. J. Trop. Med. Hyg., 27(5), 1978, pp. 897-904
Copyright © 1978 by The American Society of Tropical Medicine and Hygiene

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*Compound via MeSH
*Substance via MeSH

Levamisole in Ascariasis

A Multicenter Controlled Evaluation*

M. Moens, J. Dom, W. E. Burke, S. Schlossberg AND V. Schuermans
Department of Clinical Research, Janssen Pharmaceutica, B-2340 Beerse, Belgium, and Department of Clinical Research, Janssen R & D, Inc., 501 George Street, New Brunswick, New Jersey 08903

An analysis is presented of 10 clinical studies from various countries where levamisole 50–150 mg was compared to pyrantel, piperazine, and placebo in a total of 1,734 patients, mostly children (levamisole: 830, controls: 904), suffering from ascariasis either as a single infection or usually mixed with other nematode infections. Degree of infection and efficacy of treatment were determined by quantitative corproparasitological methods. Levamisole produced higher cure rates (91%) and egg reduction rates (98%) than pyrantel, piperazine, or placebo. The efficacy of levamisole was unrelated to the patients' sex and age, the severity of infection, the presence of another worm infection, the type of associated worm infections, or the egg-counting technique. The overall incidence of reported adverse reactions was lower after levamisole than after piperazine, pyrantel or placebo; abdominal pain and headache, the most frequent complaints after levamisole, were related to the initial severity of ascariasis. Follow-up examinations 6 months after treatment suggested that levamisole might delay reinfection.

Accepted for publication October 22, 1977.


* This opportunity is taken to pay special homage to the work and activity of the late William E. Burke, our highly esteemed and deeply mourned collaborator.

Address reprint requests to: Janssen Pharmaceutica, n.v., Turnhoutsebaan 30, B-2340 Beerse, Belgium.






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Copyright © 1978 by the American Society of Tropical Medicine and Hygiene.