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Am. J. Trop. Med. Hyg., 27(5), 1978, pp. 864-872
Copyright © 1978 by The American Society of Tropical Medicine and Hygiene

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*Substance via MeSH

Proliferative Glomerulonephritis, Hypocomplementemia, and Nucleic Acid Antibodies in Rats Infected with Trypanosoma Rhodesiense*

Herbert B. Lindsley, Raymond B. Nagle{dagger} AND Daniel J. Stechschulte
Department of Medicine, University of Kansas Medical Center, Kansas City, Kansas 66103 and Department of Pathology, University of Arizona Health Science Center, Tucson, Arizona 85724

Host immunologic responses were studied in Sprague-Dawley rats infected with a human isolate of Trypanosoma Rhodesiense. retro-orbital sinus bleedings were obtained on days 0 and 14 and at 21 or 28 days. Infected and control rats were sacrified on day 21 or 28 of the infection. Mild glomerulitis, as assessed by increased cellularity and/or widening of the mesangial region, was apparent in 6 of 7 infected animals. Finely granular deposits of IgM and IgGl were found in most glomeruli with less prominent deposits of IgGa and IgA. Focal cortical mononuclear interstitial infiltrates were present in 2 of 7 rats. Subepithelial or mesangial electron dense deposits were present in the glomeruli of infected rats. Hypocomplementemia was present by day 21 and involved both the classical and alternative pathways of complement activation. Antibodies to native DNA and single-stranded RNA were present by day 21. These studies indicate the feasibility of studying trypanosomal glomerulonephritis in rats and will provide a convenient model for detailed immunologic and morphologic investigation of host immune responses in African trypanosomiasis.

Accepted for publication May 6, 1978.


* This work was supported in part by the U.S. Army Research and Development Command (DAMD 17-74-C-4136).

Address reprint requests to: Herbert B. Lindsley, M.D., Department of Medicine, Kansas University Medical Center, Kansas City, Kansas 66103.


{dagger} Department of Pathology, University of Arizona Health Science Center, Tucson, Arizona 85724.






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Copyright © 1978 by the American Society of Tropical Medicine and Hygiene.