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Tissue Reacting Antibodies in a Rhesus Monkey with Long-Term Trypanosoma Cruzi Infection^*

Immunoglobulins (Igs) reacting against endothelial and vascular structures and striated muscle cells as well as against cells from a peripheral nerve were detected by indirect immunofluorescent test (IIF) in a rhesus monkey infected for 29 yr with Trypanosoma cruzi. Anti-T. cruzi antibodies in this monkey showed a titer of 1:128 in the IIF test and the direct agglutination test. Tissue-reacting Igs were bound in vivo to the tissues, as was established by direct treatment of a biopsy of the deltoid muscle with Ig-labeled antisera. Electron microscopy of this tissue showed that Igs reacted with the plasma membrane of the muscle cells. Neither tissue-reacting Igs nor specific antibodies were detected in three uninfected adult monkeys.

Accepted for publication January 20, 1978.

^* Made possible with funds provided by CNPq, grant no. 362 CT from FINEP and project PEPPE No. 21.1 from FIO CRUZ-FINEP.

Address reprint requests to: Ana Szarfman, M.D., Instituto de Microbiologia, Cidade Universitária, Ilha Fundao, Rio de Janeiro—20000-RJ, Brazil.