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Am. J. Trop. Med. Hyg., 27(4), 1978, pp. 758-761
Copyright © 1978 by The American Society of Tropical Medicine and Hygiene

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Comparative Evaluation of Two Dosages of Tinidazole in the Treatment of Giardiasis

A. M. M. Jokipii AND Liisa Jokipii
Department of Serology and Bacteriology, University of Helsinki, Helsinki, Finland

Forty-five patients with parasitologically confirmed symptomatic giardiasis were treated with tinidazole. A course of 150 mg twice daily for 7 days cured 14 of 19 patients (74%), and a single dose of 2,000 mg cured 24 of 26 (92%). After the single dose, mild side effects were common including maltaste, lassitude, and dizziness. Three probable cases of the so-called "postgiardiac syndrome" were seen. Either dosage of tinidazole initially cleared all stool samples of Giardia lamblia, and most clinical and parasitological failures were first detected a few weeks after the treatment. This emphasizes the significance of long follow-up periods.

Accepted for publication January 18, 1978.







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Copyright © 1978 by the American Society of Tropical Medicine and Hygiene.