AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 27(2), 1978, pp. 363-364
Copyright © 1978 by The American Society of Tropical Medicine and Hygiene

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Intradermal Test with Histamine in Schistosomiasis Mansoni*

J. Pellegrino{dagger}, Paulo Marcos Zech Coelho AND Ivan Barbosa Machado Sampaio
Schistosomiasis Research Unit, Institute of Biological Sciences, Federal University of Minas Gerais, C. Postal 2486, 30.000 Belo-Horizonte, Brazil, National Institute for Endemic Diseases, Research Center "René Rachou" (FIOCRUZ), and Department of Animal Sciences, Veterinary School, Federal University of Minas Gerais, Brazil

Histamine diphosphate was injected intradermally, at dilutions of 10-3, 10-4, and 10-5, into 25 boys (10–12 yr old), and 25 men (20–30 yr old) with active schistosomiasis mansoni. A linear relationship between the mean area of the wheals and the logarithm of histamine concentrations was determined. Both equations (men and boys) were significant (P < 0.05) but showed no difference between their regression coefficients. These findings contrast with those obtained with the intradermal test performed with Schistosoma mansoni antigens, in which skin response in men is significantly greater than in boys.

Accepted for publication July 16, 1977.


* This study was supported, in part by the Brazilian National Research Council (CNPq) and FINEP. Contribution number 89 from the Schistosomiasis Research Unit.

Address reprint requests to: Prof. P. M. Z. Coelho, C. Postal 2486, 30.000 Belo Horizonte, Brazil.


{dagger} Deceased February 1977.






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Copyright © 1978 by the American Society of Tropical Medicine and Hygiene.