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Evidence that e-Antigen is not Transmitted with Hepatitis B Infection^*

The correlation between transmission of e-antigen (e-Ag) and hepatitis B antigen (HB_sAg) was investigated in primary and secondary cases of type B hepatitis occurring in 15 families. The e-Ag was not consistently transmitted in the familial environment, as were the d and y subtypes of HB_sAg, but occurred in erratic fashion among genetically and epidemiologically related cases. It is concluded that e-Ag is probably the non-transmissible product of a specific individual response to hepatitis B infection.

Accepted for publication October 31, 1977.

^* This investigation was supported in part by grant NIH-NIAID-AI 12910-01 from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.

Address reprint requests to: Dr. V. M. Villarejos, LSU-ICMRT, Apartado 10155, San José, Costa Rica.